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Re: Good reading for those learning !!
 
dvjorge Views: 3,268
Published: 8 years ago
 
This is a reply to # 2,025,035

Re: Good reading for those learning !!


Yes, it is.
I will comment it because there are many who may get benefits of understanding it.
The fragment is part of the genial article Tissue Injured Induced by Candida Albicans written by Dr. Truss.

This fragment is an experiment with monkeys where the animals were induced a suppressed cell mediated immunity to study their response to mucosal candidiasis.

It is important for candida sufferers to know that cell-mediated immunity (Th1/Th17) is the immune response that defend us against mucosal yeast colonization.

Most people know the immune system has two main branches, Th1/Th17 and Th2.

Th1/Th17 is the defense we have against organism that get inside the cells, intracellular pathogens, for example a yeast such as candida albicans. Th2, also known as a humoral immunity is an antibody response against extracellular intruders that are found in body fluids.

The ideal is to have a balanced Th1/Th2 immune system.
Unfortunately, there are many offenders that polarize the immune system in a chronic Th2 mode depressing or canceling Th1.
When this happen, chronic mucosal candidiasis affect us.

When scientific experimented with monkey, they noticed that during an active Th1 response, mucosal candida infections cleared. But, when they induced a depressed cell-mediated immunity, the immune response was increased in a Th2 mode allowing the fungus to proliferate and the immune system wasn't able to eradicate the infection.
They also noticed that when the infection proliferated there was candida albicans morphogenesis and unicell disruption to form mycelia. It is just when candida cells break to germinate that mannan, a yeast glycoprotein with powerful cell-mediated immune suppression power is released and gets the bloodstream causing more Th1 suppression.

So, the transition of yeast to mycelia in the intestines is a factor that creates cell-mediated immune suppression caused by the absorption of mannan by the gut lining.

I brought this fragment to the forum to highlight that rescuing cell-mediated immunity is the only way to eradicate persistent and unresponsive mucosal yeast growth.

Until the competent cell-mediated immunity don't be active, there isn't antifungal therapy that conquer the infection.

It is well known that medicines supports the immune system against an infection but the main battle is played by an immunologic response.

Jorge.

 

 
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