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Re: Methimazole prevents iodine and peroxidase from their normal interactions with thyroglobulin to form T4 and T3....
 
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Re: Methimazole prevents iodine and peroxidase from their normal interactions with thyroglobulin to form T4 and T3....


 

 

www.medicinenet.com/methimazole/article.htm

 

DRUG CLASS AND MECHANISM: Methimazole is used to treat an overactive thyroid gland (hyperthyroidism). Grave's disease is the most common cause of hyperthyroidism. It is an autoimmune disease resulting from antibodies that attach to receptors on thyroid hormone-producing cells in the thyroid gland and trigger overproduction of thyroid hormone. Anenzyme (peroxidase) produces thyroid hormones, i.e., thyroxine (T4) andtriiodothyronine (T3), by combining iodine with a protein calledthyroglobulin. Methimazole prevents iodine and peroxidase from their normal interactions with thyroglobulin to form T4 and T3. This action decreases thyroid hormone production. Methimazole also interferes with the conversion of T4 to T3. Since T3 is more potent than T4, this also reduces the activity of thyroid hormones. The FDA approved methimazole in March 1999.

 
 

 
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