I actually had tried Betaine HCL by itself and it seem like the more I took the worse my stomach felt. I was actually having stomach cramps. I went back to taking Omeprazole 20mg. I very seldom take the betaine. I believe the ingredients are different. Sometimes you may need a combination of things. Some people get by with just Protonics or some other type of acid blocker.
Some get away with with aloe vera juice and probiotics for acid reflux. You have to really get to know your digestive system a little better. I don't take the Omeprazole every day but I do sometimes take ACV for my ph balance.
You may have to do more research for yourself before you find something that really works for you.Even though you are taking the acid blocker you should still take something like probiotics or digestive enzymes to do more.