"Choline is definitely a nutrient needed in good supply for good health. Choline is a key component of many fat-containing structures in cell membranes, whose flexibility and integrity depend on adequate supplies of choline. Two fat-like molecules in the brain, phosphatidylcholine and sphingomyelin, account for an unusually high percentage of the brain's total mass, so choline is particularly important for brain function and health.
In addition, choline is a highly important molecule in a cellular process called methylation. Many important chemical events in the body are made possible by methylation, in which methyl groups are transferred from one place to another. For example, genes in the body can be switched on or turned off in this way, and cells use methylation to send messages back and forth. Choline, which contains three methyl groups, is highly active in this process.
Choline is also a key component of acetylcholine. A neurotrasmitter that carries messages from and to nerves, acetylcholine is the body's primary chemical means of sending messages between nerves and muscles.
"More than 90% of Americans are choline-deficient. An assessment American's dietary choline intake by Iowa State University researchers (Jensen H, Batres-Marquez S, et al., FASEB Journal) revealed that for older children, men, women and pregnant women, intake is dramatically below Adequate Intake (AI) levels, with only 10% or less of all these groups getting even close to recommended amounts of choline"