So much of the difference in response is personal. I use both Iodoral 50 mg and SSKI (45 mg iodide in 2 drops). My body experiences iodine as "darker" and iodide as "lighter." For the 20 mg of iodine in Iodoral 50 mg, apparently I need 75 mg iodide to balance. I can feel sluggish on too much iodine, and speedy on too much SSKI. Both DH & mother use 4 drops of SSKI daily, but I feel a need for iodine to balance. And I always use the companion supplements.
Much of this you simply have to figure out for yourself. That's the adventure :)