I'm surprised no one mentioned the possibility of mercury (Hg) as the underlying or an underlying factor. It can cause all of those symptoms.
Hg has a negative effect on copper-zinc balance. It also has negative effects on the liver and this can negatively affect excretion of Copper.
Hg affects the body's stress response system in many ways! This is very common in the chelation groups, especially among women. Hg affects pituitary stress hormones, hormone receptors, adrenals, etc.
Hg also has a negative effect on magnesium (Mg) levels. Mg is used to make maybe the most important antianxiety chemical in the body, GABA. Mg is also used to make one of the body's antidepressants, serotonin. The effects on Mg might also produce tendencies towards constipation, muscle problems, etc!
When a person has an untreated Hg problem the use of NAC and especially ALA can exacerbate the Hg problem, including anxiety.
Sadly this recently happened to a very close female friend. She had been doing so well after silver-mercury Amalgam filling removal and several months of low-frequent dose oral DMPS (Cutler protocol).
According to A. Cutler's theory about Hg's effects on the movement of essential elements into hair, her older test suggests the involvement of Hg. The second is only suspicious.
I've read many other reports from people who innocently used ALA infrequently or with Amalgam fillings still present. There are several reports below. Some actually had gains in some areas initially but then realized damage was being done, usually to the brain, as Hg levels there likely increased.