I agree that the Cutler protocol may not be a successful protocol for everyone. I spoke with someone at DAN and he said that the Cutler protocol is about 9 years old and considered outdated. There are other protocols that are safer (e.g. OSR). I stopped using the Cutler protocol a couple of months ago and began using DHLA Nano Plex and have had remarkable results. I use it in addition to taking the following Liver Cleansing herbs (Liver Life and Liver Complete) for three to four weeks.