Excess bile definetly irritates my gut lining and causes nausea...this might apply more to excessive intake/application of bile promoters that come in direct contact with intestinal lining. It might be worth expermenting with if taken with a meal. Experiment with the doseage. The dews bile salts are probably one of the most bitter things ive ever tasted...it doesnt take much. Inhibitors may help with the battle but unfortunately dont win the battle.
Anything that can excessively irritate the lining of the gut, which causes an inflammation response..probably does not help leaky gut.
Good post on bile:
Another interesting abstract with bile salts. It can be frustrating how pathogens can mutate and become resistant.