Somewhere I have rants on methylation. The point being that if SAMe is truly broken there are other issues in the brain.
Mostly not the case, mostly methylation is broken lower down the ladder. Homocysteine or 5HTP have some very important pathogens that work against those steps.
My rule of thumb is if its in the Head treat Borrelia Garinii twice a day and the rest will come out once the immune suppressive function of that flavor of Lyme are gone. Forced immune suppression is the game the NWO plays on the sheople..
The other one is the enzyme in Malt, that is a MUST for brain clearance.