Like so many things, I think this comes under the heading, "Your Results May Vary." I've read reports of people feeling really good taking pregnenolone. I was leery of it for myself, so got blood tests for hubby and me. We both tested low. We took 50 mg each. Soon, hubby had an emotional meltdown, and I was so ramped up I couldn't sit still. Put it on the "Never Again" pile.