fish tape-worm infection treated with paromomycin

[A case of fish tape-worm infection treated with paromomycin and an observation on its mode of action. II. With special reference to aminosidine (author's transl)].
[Article in Japanese]
Kanazawa Y.
Abstract
A female adult suffering from fish tape-worm infection was successfully treated with a single oral administration of 4,000 mg aminosidine, a paromomycin. The drug concentration in the segments of the worm removed were as high as 600 mg/ml or more, meanwhile, serum level and urinary recovery in the patient were very low. Consequently, it was presumed that some acute effect, such as neuro-muscular toxicity, of the drug, which was well absorbed into parasite, but ill-absorbed from the gastrointestinal tract of human, is one of the mode of antihelminthic activity, in this case.
PMID: 857058 [PubMed - indexed for MEDLINE]
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