I went on a high dose of Nexium for GERD. Within a month I started experiencing recurring episodes of SEVERE pain in the area of my sternum/solar plexus. These episode occurred approximately once per month and lasted 10-15 hours. It was excruciatingly painful.
Two of my doctors believed that the symptoms were indicative of gall bladder pain. Sonogram was negative for gall stones. A HIDA scan indicated that my gall bladder was not functioning properly. My Dr. recommended gall bladder removal. However, I discovered research that concluded that proton pump inhibitors such as Nexium actually cause gall bladder dysfunction (http://www.medscape.com/viewarticle/503676).
I switched from Nexium to omeprazole and am taking about half the dose I was before. The painful episodes have completely discontinued. And I still have my gall bladder.