the vast majority have no trouble, but its always the problems that get talked about.
IF a person is going to have a bad detox reaction then 50mg will be enough to bring it on but not enough to mitigate the effect of the added toxins that are released. 100mg takes care of that. also, ANY detox is the worst the first time Iodine is taken. it quickly subsides after that. two things that are counterintuitive about Iodine supplementation.