Yeah, die off can make me feel about as miserable as I've ever felt. What I hate is to feel irritable and react to things that may or may not annoy me. I mean, I think being annoyed may have been justifiable, but die off seemed to magnify it.
When I was on Nystatin in the mid 80s, I seemed to be ahead of Candida on a certain dose of it (when I was in truck driving school) but later on, had to quit Nystatin because I started to get "die off" on any dose of it, and that's when the gunk in my intestines probably grew. Ever since then I felt like I was trying to empty the ocean with a thimble when trying to clean out my GI tract. I have some major gunk in there. I hope to get it out of there ASAP. It's no wonder my health has been good but not great. I don't see how anyone could feel good with 5 pounds of rotten, smelly, slime inside of them, and who knows what else..