I'm more quick to believe my symptoms are associated with unwanted organisms. I have gotten cold in my feet and hands but rarely. It was when I was close to my worst. I have read it can be a sign of nutrient deficiency which I believe was the case. My weight has been consistent and Depression has not really been an issue unless I get hit with high levels of dieoff or toxins from organisms digesting leftover food. I will consider the thyroid again if after I am done with my cleanse I am still experiencing hairloss and all other symptoms go away. It might be my thyroid being affected. I believe it is more likely something is throwing my natural processes off than just my body suddenly having multiple things going on wrong.