I did a 60 day Colon Cleanse (Dr. Natura/Colonix) and then I went to the renew life liver detox for 6 weeks. It did a good job and I slept and felt really well. I did see a few stones. I would definitely say to get the keep the bowels moving with the Colon Cleanse first. I also use enzymes with my meals and a green drink as my "vitamins". I think these two things also have a cleansing effect. I have done 2 flushes with good results both times. I have since added just milk thistle and that seems to work for me. Good luck.