Shake well before you use and do right before you go to bed so that you can lay on your back and let the solution dry inside your nose and sinuses. Just do 2 nights as you may irritate your sinuses. Also don't put anything else in your sinuses or you may kill off the friendly bacteria. When the fungus is gone you will notice a clear liquid replacing the bad stuff. Something like the clear liquid on the top of your yogurt. Let me know how it works for you. Will have a booklet and web site up in a couple months has it all there so you know the details. Feel free to email me if you have any questions. (-: If you have Chronic Sinusitis as defined you will be amazed.