Lugol's is corrosive enough to eat away at the rubber dropper seal, not so with nascent. Inside the body this oxidation can exhibit itself as nasal cavity irritation, among other sides.
In general, we also know that ionization, for better or worse, increases bioavailability. I've also witnessed nascent Iodine create an unmistakeable electrically charged reaction when added to Lugol's or water. To every action there is always an equal and opposite reaction. Just in case, I personally dose with both and plan on trying all existing Iodine formulations.