Yeah I've experienced die-off before. It was flu like symptoms that didn't last long. The headache I had when I was on diflucan persisted and didn't go away. Typically, if I get a headache I can sleep it off, but this one would not go away. I'm wondering if people just put up with the headaches and continue with the medication. Well, I'm going to give it another try. I'm on day 3, so far so good.