1) Use a co-enzymated form from Country Life, where co-enzymated means that the liver does not need to process, so they are ready to go.
2) Choline/Inositol which the choline is the better of the two since it is involved in methylation.
3) TMG is also a methyl donor.
4) Favor extra B2 and B6.
5) folic acid and methylcobalamin (B12) are involved as methyl donors.
Amino Acids::
I had an amino acid test done and was helpful in identifying problems with the cysteine/taurine/methonine pathways. These are all sulfur donating amino acids and involved in the liver detox pathways. Glutathione as mentioned before is essential in which cysteine is one component of glutathione. SAMe is a specialized form of methionine and is expensive, some report good results. I did not have those results and used straight methionine.