JC liver stuff Part I

JC:

Well the liver is always going to be an issue for people suffering with immune difficulties. One of the bigger things I found was the role of Glutathione in these conditions. Glutathione is considered one of the master detoxifiers of the body. It is a tri-peptide meaning that 3 amino acids are necessary for its production, cysteine being one of them.

Glutathione has a dual-role.

1) It is a detoxifier of many substances, utilized in the liver etc.

2) It is a key component of the immune system.

My theory is this:: We become vunerable to disease when glutathione stores become depleted. If you are attacked with toxins (particularly heavy metals such as mercury, which by the way attack the thiol groups of amino acids in which the key amino acid cysteine is part of the thiol groups) then glutathione is depleted. By depleting glutathione then the immune system becomes weakened. When the immune system becomes weakened then become more vunerable to pathogenic attack. So if we become weakened with pathogenic attack then glutathione stores are depleted which leaves us vunerable to toxins. And the cycle continues until either the body becomes rebalanced with nutritionals such as vitamin C, magnesium, b vitamins, essential fatty acids etc., or the pathogenic invasion is stopped or toxins are removed or any combination.

http://www.articlesbase.com/supplements-and-vitamins-articles/chronic-liver-d...


The problem with glutathione supplements is that since it is a tri-peptide, if taken orally, then stomach acids will attack the tri peptides which lead them non potent. I use a product that is protected by liposomes which is the latest greatest product, it is called Readisorb*. Cysteine is another choice that is quite good.

*If anyone is interested in Readisorb, I can obtain this wholesale and pass on the savings - cost would be $40 per bottle versus $65 wholesale. (I would state that I am not posting info about this to profit from it) PM me if interested. Another option would to use NAC or cysteine, the latter being the cheaper method. But you would need to use with the methylation co-factors as outline below.

Also methylation I think plays a key role in liver health

Methylation

Methylation involves conjugating methyl groups to toxins. Most of the methyl groups used for detoxification come from S-adenosylmethionine (SAM). SAM is synthesized from the amino acid methionine, a process which requires the nutrients choline, the active form of B12 --methyl cobalamin, and the active form of folic acid --5-methyltetrahydrofolate. SAM is able to inactivate estrogens (through methylation), supporting the use of methionine in conditions of estrogen excess, such as PMS. Its effects in preventing estrogen-induced cholestasis (stagnation of bile in the gall bladder) have been demonstrated in pregnant women and those on oral contraceptives. In addition to its role in promoting estrogen excretion, methionine has been shown to increase the membrane fluidity that is typically decreased by estrogens, thereby restoring several factors that promote bile flow. Methionine also promotes the flow of lipids to and from the liver in humans. Methionine is a major source of numerous sulfur-containing compounds, including the amino acids cysteine and taurine.





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