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Nasty stuff!
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Published: 16 years ago
This is a reply to # 158,651

Nasty stuff!

Below is some information on Prednisol. It is primarily metabolized in the Liver and raises the ALT/AST liver enzymes. It is excreted through the kidneys. It is not advised for those with fungal infections.

I would not stress either liver or kidneys while taking this medication. No alcohol or liver flushing, no cleansing herbs. Eat a low protein diet to protect the kidneys. Eat lots of vegetables, veggie juices and nuts to replenish the minerals depleted by the drug. Drink lots of pure water.


Nutrients Depleted: Calcium, Folic Acid, Magnesium, Potassium, Selenium, Vitamin C, Vitamin D, Zinc

Pregnancy Risk Factor and Implications: B; some corticosteroids are known to enter breast milk/use caution.

Contraindications: Hypersensitivity to individual corticosteroid agents or formulations, fungal infections, serious infections (Note: There are specific exceptions to this general contraindication such as bacterial meningitis in selected patients).

Warnings/Precautions: Withdrawal of therapy must be done gradually, use may retard bone growth, use with caution in patients with hypothyroidism, cirrhosis, hypertension, congestive heart failure, diabetes mellitus, ulcerative colitis, thromboembolic disorders, and patients at risk for peptic ulcer disease. Use the lowest possible dose for the shortest possible period of time. Adverse effects may be particularly common in the elderly.

Adverse Reactions: Signs and symptoms of systemic hypercorticism and suppression of the adrenal-hypothalmic-pituitary axis may occur when used for prolonged periods. Cushingold appearance, muscle weakness, and osteoporosis may result. Individual corticosteroids may vary in their potential to cause specific adverse effects. The listing below provides only a general indication of the spectrum and frequency of adverse reactions to corticosteriods.

Greater than 10% experience:

Central nervous system: Insomnia, nervousness
Gastrointestinal: Increased appetite, indigestion

1% to 10% experience:

Dermatologic: Hirsutism
Endocrine & metabolic: Diabetes mellitus
Ocular: Cataracts, glaucoma
Neuromuscular & skeletal: Arthralgia
Respiratory: Epistaxis

Less than 1% experience:

Edema, hypertension, vertigo, seizures, psychoses, pseudotumor cerebri, headache, mood swings, delirium, hallucinations, euphoria, acne, skin atrophy, bruising, hyperpigmentation, Cushing's syndrome, pituitary-adrenal axis suppression, growth suppression, glucose intolerance, hypokalemia, alkalosis, amenorrhea, sodium and water retention, hyperglycemia, peptic ulcer, nausea, vomiting, abdominal distention, ulcerative esophagitis, pancreatitis, muscle weakness, osteoporosis, fractures, muscle wasting, hypersensitivity reactions

Overdose/Toxicology:Symptoms of intoxication include cardia disturbances, CNS toxicity, bronchospasm, hypoglycemia, and hyperkalemia. The most common cardia symptoms include hypotension and bradycardia. Atrioventricular block, intraventricular conduction disturbances, cardiogenic shock, and asystle may occur with severe overdose, especially with membrane-depressant drugs (eg, propranolol). CNS effects include convulsions and coma. Respiratory arrest (commonly seen with propranolol and other membrane-depressant and lipid-soluble drugs). Treat symptomatically. Cardiac and hemdynamic monitoring may be necessary.


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