Hi Kir - Yes, I can relate. I've been dealing with Depression for 33 years, and a variety of other conditions (adrenal fatigue, bipolar, sluggish liver, hypoglycemia, suicidal tendencies, etc.) for almost as long. You can read some of my old posts to get a sense of what my experiences of this have been like.
But enough about me. For depression, I suggest you read "The Mood Cure" by Julia Ross. As far as your fatigue--have you ever been tested for adrenal fatigue? I skimmed some of your posts, and didn't see any references to colon, kidney or liver cleansing. Have you ever done any of these? You might want to check out http://www.drlwilson.com
and http://www.arltma.com
for articles on a variety of topics related to your conditions.