Some stones are larger than others of course - using Chinese Gold Coin Grass and malic acid and orthophosphoric acid will help to break stones down, you might have to work on the really big ones for awhile, but they are in the minority, usually one big calcified stone, not a gall bladder full of them.
Me I haven't had anything I couldn't tackle in 12 flushes, knock on wood. Of course you want stones to keep rolling out of your liver to your gall bladder to keep the process going, til you are out of them, or your symptoms are manageable. The GCG will encourage that process.
The only problems with pain I experienced afterwards were when I didn't get a colonic - those two times I got pain and sickness. That is because after a few days the toxins recirculate, so it is important to get cleaned out in time. I did get that fixed one time with the help of a good kinestiologist.