I don't think the Milk Thistle is giving you the itchies. When I itched so bad that I bruised myself, I was told by a Dr. that, that was a liver problem. Obviously if you are taking Milk Thistle there must be a reason why. I would suggest you do a liver flush. You can do it in a day and it isn't hard to do at all if you use fresh grapefruit juice along with both the epsons salts & the olive oil.