You will always have more trouble (from people) if you go somewhere comfortable. The best way to avoid trouble is to live somewhere remote, with harsh conditions. Low population density for a reason. That cuts out "lots of culture" and "not too hot / cold" usually. It needs to be a place where you can still get food and water, somehow, but it may be more difficult. Somewhere without services, so no cell towers and no internet access, probably. Some of those areas, though, are where some of the worst pollution occur, precisely because nobody lives out there.
And don't live in MS or VA (I think it's Virginia, but definitely Mississippi) if you ever have kids and don't plan on vaccinating or on being selective about which vaccines! They can take your kids - unless you shoot them first.