My wife and I got prazi and have gone through a whole 50g jar. We got more. We did not notice even one real side effect, except nausia. But I was already nauseous about this topic. Big deal... We got much relief with visible and tactile results. We did our internal cleansing. Of course if one does not do their enemas, coffee enemas, and occasional liver flushes, it WILL be hard on the liver, but IMO that's from the die off. I'm thinking prazi is the first thing to take [but after colon cleansing and initial liver flushes], possibly even before the herbs. Everyone is different, of course, with different levels of health, different mix of bugs, etc., so I still reserve the right to be wrong. Each person has to educate themselves to make good choices on what is right for them, but for me, taking prazi has been the biggest no brainer so far. I was initially hesitant, which was completely unfounded.