It's happened to me twice, in two phases. I've lost a lot of 'friends', all people who couldn't crawl out of their box to see what I was trying to get them to observe. Interestingly enough, it's true that God never closes a window without opening a door. The people that came to fill their places are open minded, loving and exploratory about their personal growth. The first time is when I lost multiple family members in a short period of time and consequently had a breakdown.
People said 'ya know, everybody loses family members, you're being ridiculous and selfish.' Know what? None of those people have lost one family member to suicide, let alone 2 nuclear family members.
I'm learning a lot of compassion while I'm on this planet, I'll tell ya.
The second time is when I detracted from 'normal' life to begin healing my body.
Everybody (including 2 MD's) said 'it's all in your head and if you just stop thinking about it - you'll be fine.'
There's a perspective on transmutation in that God chooses people to hold something, to be an example to others - good and bad. Many of us are 'sensitive' and can't deal with the toxicity of everyday modern life (deodorant, dryer sheets, what have you) and we first become 'weirdos' for choosing to step outside of the grain and do things more simply. They don't see it as doing things more simply. But - one by one, it's happening to others. Why is that? Because when it happens for others, who do they look to? It's not that now we/you're in a position of power - it's an example - it's an epidemic. People are getting ill all over the place and sooner or later - they have to schleff off that luxury for the more simple, really luxurious version - to love yourself enough that you know you're perfect and worthy of boundless love and healing.
Darwinism is coming. When the crossroads happen for people, they'll either choose to pull their blinders away and see the bigger picture...or not. Free will is a tricky thing.