I've done two in the daytime. I couldn't tell any difference except it was easier than having to lay all night too sick to sleep. I started my ES about 4 a.m. and drank my OO (Olive-Oil) about 8:00 a.m. and lay in bed for 2 or 3 hrs after drinking oil. It was much easier, it was a workday and I had the house to myself. Keep us posted on how you do!