If I wake up in the middle of the night, generally valerian (but not 100% of the time) will put me back to sleep. A couple of times it seemed like the Sleep Eze actually made me more awake. Maybe it was an exceptionally bad night. I have read Hops is estrogenic, maybe the Hops messed with my hormones more and made it harder to fall back to sleep. Or maybe my body had already had enough sleep on those particular nights.