The problem comes when flushes aren't enough. If impacted with parasites and bacteria then holding onto it would be difficult but doable.
Even after removing the GB those issues almost always return, not something they advertise.
Key infections are flukes, dwarf Tapeworm (Lead), T.solium cysts, GB type bio-weapons, Aflatoxins, Gallbladder<->Hypothalamus connection issues (Mercury) and things like fast phase I liver cycle due to Mercury toxicity.
When my GB area acts up I apply a Terminator II zapper to the sole of my right foot for several hours. Organic/inflammatory blockages usually begin to get better after 30m or so, Mag Malate helps to free any small stones.