A few thought: You began Iodine Oct 20 and speak of your PMS having gotten better at first, then worse, as well as specific breast symptoms now. This bout of worse symptoms [PMS} that you are talking about is probably your second menstruation since starting the iodine?? A woman ovulates from alternate ovaries in consecutive months,so the ovary involved this time is NOT the one that was involved in the first period after you started Iodine unless this will be the 3rd period since you started iodine. Other than that the only thing I can think of is that, obviously, you have more Iodine in your system now than you did at the first period after you started iodine so might be getting a stronger effect from that reason? The other factors you mention I have no experience with.