I like your input on vitamin E. L-selenomethionine is a good anti-oxidant but it does not appear to be the best form of selenium for fighting cancer.
Different Forms of Selenium
Inorganic forms of selenium such as sodium selenite have proven
more effective at fighting cancer than the commonly used organic form,
selenomethionine, yet selenomethionine was more effective at
increasing selenium tissue levels and glutathione peroxidase activity.
Because cells cannot distinguish selenomethionine from the essential
amino acid methionine, some selenomethionine becomes incorporated into
general body proteins, increasing tissue selenium levels.
Selenomethionine general proteins have no anticancer activity
while sodium selenite is more frequently metabolized to the toxic
metabolite hydrogen selenide (H2Se). Hydrogen selenide does have
anticancer effects but it is more toxic than selenomethionine. Its
primary mode of killing cancer cells (and at high levels, normal
cells) is through the process of cell necrosis. Cell necrosis provokes
inflammation and may kill healthy cells along with cancer cells.
More recent anticancer research has focused on the compound
Methyselenocysteine. Methyselenocysteine is found naturally in some
vegetables including garlic, brassicas, leeks, and onions, especially
when these are grown in high selenium soil. Methylselenocysteine is
easily converted to methylselenol which has been demonstrated to be an
effective anticancer form of selenium. Rather than killing cancer
cells by necrosis, methylselenol kills cancer cells through apoptosis.
Apoptosis is a orderly process of cellular self-destruction that does
not provoke inflammatory responses. Methylselenol is also known to
inhibit angiogenesis in beginning cancer tumors. Angiogenesis, the
creation of new blood vessels, is necessary for cancer cells to grow
into a tumor.
Methylselenocysteine does not accumulate in the body and is
considered to be non-toxic.