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New Study: Pathways in Antiprolif. Effect of Iodine in Breast Cancer Cells
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New Study: Pathways in Antiprolif. Effect of Iodine in Breast Cancer Cells

Good afternoon,

Cited below is the abstract for the new Aceves Group study, "Signalling Pathways Involved in the Antiproliferative effect of Molecular Iodine in Normal and Tumoral Breast Cells: Evidence that 6-Iodolactone Mediates Apoptotic Cells."

SUMMARY: Iodine exerts its cancer-killing capability in Breast Cancer cells by binding with high concentrations of polyunsaturated fats found in breast tumors.

Breast Cancer Choices

1: Endocr Relat Cancer. 2008 Sep 30. [Epub ahead of print] Links
Signalling pathways involved in the antiproliferative effect of molecular Iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects.
Arroyo-Helguera O, Rojas E, Delgado G, Aceves C.
O Arroyo-Helguera, Instituto de Neurobiologia, UNAM-Juriquilla, Universidad Nacional Autonoma de Mexico, Juriquilla, Mexico.

Previous reports have documented the antiproliferative properties of molecular iodine (I2) and the arachidonic acid (AA) derivative 6-iodolactone (6-IL) in both thyroid and mammary gland. In this study, we characterized the cellular pathways activated by these molecules and their effects on cell cycle arrest and apoptosis in normal (MCF-12F) and cancerous (MCF-7) breast cells. Low to moderate concentrations of I2 (10-20 muM) cause G1 and G2/M phase arrest in MCF-12F, and caspase-dependent apoptosis in MCF-7 cells. In normal cells, only high doses of I2 (40 muM) induced apoptosis, and this effect was mediated by poly (ADP-ribose) polymerase-1 (PARP-1) and the apoptosis-induced factor (AIF), suggesting an oxidative influence of iodine at high concentrations. Our data indicate that both I2 and 6-IL trigger the same intracellular pathways and suggest that the antineoplasic effect of I2 in mammary cancer involves the intracellular formation of 6-IL. Mammary cancer cells are known to contain high concentrations of arachidonic acid, which might explain why I2 exerts apoptotic effects at lower concentrations only in tumoral cells.

PMID: 18827038 [PubMed - as supplied by publisher]

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