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lilypond10 Views: 5,721
Published: 13 years ago
 
This is a reply to # 1,276,835

Lung Cancer Study


I've quoted the breastcancerchoices.org comment below on the lung study....this is really good stuff.
Lily

     Cited below is the first study referenced by Dr. Flechas, a UCLA study in which not only the NIS symporter, but thyroperoxidase (TPO) as well were put into a retrovirus that was put into mice with oat cell lung cancer
     The significance of adding TPO to the NIS is that TPO helps to oxidize iodide to form iodine to make hormones and bind to fats to form iodolactones to kill cancer cells.
     Then iodide was given to the mice - NONRADIOACTIVE IODIDE!
     With all of the NIS to help the iodide get in,  more than 95% of the mice's oat cell lung cancer cells were killed.  Way cool.
     What great UCLA researchers to try using nonradioactive iodide to kill the lung cancer!
                
 

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[Cancer Research 63, 5065-5072, August 15, 2003]
© 2003 American Association for Cancer Research


Regular Articles

Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells1

Ling Zhang , Sherven Sharma , Li X. Zhu , Takahiko Kogai , Jerome M. Hershman , Gregory A. Brent , Steven M. Dubinett2 and Min Huang2

Division of Pulmonary and Critical Care Medicine [L. Z., S. S., L. X. Z., S. M. D., M. H.], Division of Endocrinology and Metabolism, Department of Medicine [T. K., J. M. H., G. A. B.], Lung Cancer Research Program of the Jonsson Comprehensive Cancer Center [S. M. D.], and Department of Pathology, David Geffen School of Medicine [M. H.], University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, California 90073


    ABSTRACT

 
We assessed a nonradioactive approach to induce apoptosis in non-small cell lung cancer by a novel iodide uptake and retention mechanism. To enhance tumor apoptosis, we transduced non-small cell lung cancer cells with retroviral vectors containing the sodium iodide symporter (NIS) and thyroperoxidase (TPO) genes. Expression of NISand TPOfacilitated concentration of iodide in tumors. As a consequence of the marked increase in intracellular levels of iodide, apoptosis was seen in >95% of NIS/TPO-modified lung cancer cells. Intraperitoneal injection of potassium iodide resulted in significant tumor volume reduction in NIS/TPO-modified tumor xenografts without apparent adverse effects in SCID mice. Iodide induced an increase in the level of reactive oxygen species. Iodide-induced apoptosis is sensitive to N-acetylcysteine inhibition, suggesting an important role by reactive oxygen species in this apoptotic process. In addition, iodide-induced apoptosis is associated with overexpression of CDKN1A (p21/Waf1)and down-regulation of survivin at both mRNA and protein levels. This is the first report demonstrating that a therapeutic dose of nonradioactive iodide has potent efficacy and high selectivity against lung cancer when used in combination with genetic modification of cancer cells to express the NIS/TPOgenes.



 

 
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