ALA is NOT specific enough for me to use in large amounts yet. The only dose I can tolerate is 12.5mg.
When I treat Lyme after which I have a lot of Brain mercury I switch to RLA use 150mg every 20m until those symptoms are gone.
NOTE: Using RLA for this while blood Hg levels are high may make things worse. This is why one MUST remove extra cellular Hg with DMSA *first*. In short RLA appears to be very specific for opening the BBB, but that is a two way street and high serum Hg will find its way into the brain.