This WAP doc and others all premise their recommendation on the belief that if you manipulate one form of estrogen into another form of estrogen, the patient will have the same blood profile as a healthy breast person.
This theory is speculative but has been given wide publicity. I would like to see this proved. Then I will publicly reverse all my objections.
I feel it is like observing that a number of cardiac patients (true) have a deep crease in their ear lobes. If you cut off their earlobes or do surgery to plump up that crease, you will not change the correlation. A correlation is often mistaken for a cause.
This may be the case with the estrogen rangers. They are hunting and blocking estrogens, thinking they are addressing a cause, not a correlation. What if the estrogens are a compensation mechanism?