I did read an article from a doc who has a successful practice using UT and he says although smokers and bad diet etc. are not helping the process, but he says his people who do still show great improvewment and to not let these things stop you, because there is always benefits from UT even for them ! Beside the metabolites help the body read your personal code and adjust accordingly! It wouldnt stop me ! It may help someone get of such meds!