I've done several and had good luck with them and I have leaky gut. If you search this forum, you'll find lots of opinions about liver flushing. It cleared alot of crap out for me, but before I started doing them, I took milk thistle for almost 2 years and was following a candida diet. We all have different levels of tolerance for protocols, it's not a "one size fits all" type of condition. Sure would be easier if it was. If you haven't checked it out, there is also a Liver Flush Support Forum . Good Luck!