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Re: for the sake of your unborn children
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Published: 14 years ago
This is a reply to # 1,126,766

Re: for the sake of your unborn children

Hey, Wombat! nice of you to drop by...

So, supplementing of mms relative to parkinson's needs some real valid research to be done and/or some on point testimonials from those that are giving it a go. And, if one is going to supplement, then sticking to the lower doses over time rather than the slam-dunk approach would be the way to go, imo... balancing with higher doses of b3, coenzyme Q10 to protect against dopamine depletion... Anybody?
Implications for Treatment
Parkinsonism, multiple sclerosis and amyotrophic lateral sclerosis each appear to involve an Iodine deficiency before and immediately after birth, which affects the dopaminergic system. In adulthood, this abnormality seems to increase susceptibility to the oxidation of dopamine and to an associated glut of cytotoxic glutamate. If this hypothesis is correct, it implies treatment avenues that should be further explored. Firstly, levodopa seems likely to be beneficial in all three disorders, but should probably be accompanied by vitamin B3 and coenzyme Q10. Shulz and coworkers,59 for example, have found that, in animals given Parkinsonism by the administration of MPTP, vitamin B3 and coenzyme Q10 provide protection against dopamine depletion and, therefore, help prevent the psychotic effects of its associated oxidative byproduct, dopachrome. This may explain Hoffer’s success in adding high doses of vitamin B3 and coenzyme Q10 to the normal treatments for Parkinsonism.36

Secondly, all three disorders appear to involve the depletion of the enzymes which protect against oxidative stress, Cu/Zn superoxide dismutase, glutathione peroxidase and catalase. This may be why anti-oxidant supplementation, especially selenium, vitamin E and vitamin C, is now recommended for multiple sclerosis patients.60 It also may account for some of the success of the Swank diet61 in the treatment of this disorder, since this diet is very high in the antioxidant vitamin A and in the essential fatty acids, which are easily oxidized and create prostaglandin deficiencies. Beyond this, Apostolski and coworkers44 have shown, in clinical trials, that the course of amyotrophic lateral sclerosis can be slowed by the administration of selenium, other antioxidants, amino acids, and a Ca2+ channel blocker such as nimodipine. Only the use of all of these components together enhanced glutathione peroxidase activity, increased plasma vitamin E levels and appeared to slow disease progression. Hoffer and Walker 62 also have discussed the long-term survival (22 years) of an amyotrophic lateral sclerosis patient receiving coenzyme Q10, selenium, zinc, dolomite, niacinamide, thiamine, folic acid and vitamin E. Thirdly there would also seem to be a role for glutamate antagonists in all three disorders. Finally, given the apparent relationship between Iodine and dopamine, it seems logical to further explore the value of this mineral in the treatment of these neurologic diseases.


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