The problem here isn't the Miracle-Mineral-Supplement , but the concentrated fructose present in the fruit juice. Glycation is a process by which the elements in the blood become "sugar-coated" and prone to greater oxidative processes. These generate the very arterial changes seen in diabetes. The delicate vessels of the eyes, kidneys and areas of circulation furthest from the heart (i.e., feet) are initially the most susceptible to damaging changes and impaired circulation. In men, erectile dysfunction is commonly associated with these same processes.
The body is normally obsessed with maintaining blood Sugar within a very narrow margin of concentration in the bloodstream, optimally between 80 or 85-100 mg/dL---Only about 5 grams of glucose (about a teaspoon) circulates in the bloodstream at any given time. This is strictly maintained primarily by two pancreatic hormones: insulin and glucagon. Insulin's job is to make absolutely certain glucose doesn't accumulate past a certain level in the bloodstream, as it has an extremely damaging effect. Insulin's job is to remove the Sugar from the bloodstream and transport it to cells where it can be used for energy. Any excess is then converted to triglycerides and transported to adipal cells for storage as body fat (a much more labor-intensive and energy demanding process---fatigue after meals is a classic sign of insulin resistance). Glucagon, conversely, mobilizes the glycogen reserves in the liver to raise blood Sugar so that it doesn't drop too low between meals. If a person consumes a high carbohydrate diet continuously (which we were never, ever designed to do) then the constant bombardment of cells by insulin begins causing a breakdown of cellular receptors sensitive to this hormone. It starts to take more and more insulin to do the same job until, finally, the cells are so resistant to insulin that blood sugar is elevated all the time....a condition known as diabetes.
A meal particularly high in high glycemic carbohydrates (sugar, cereal, bread, potatoes) will cause a huge spike in blood sugar stimulating a massive release of insulin to counter this. It is important to understand that our ancestors never really had an emergency need to LOWER blood sugar. As such, the body's response to such an emergency is crude--and excess insulin will drive blood sugar down faster than glucagon can manage. The next thing in line designed to catch and correct this (our safety net, of sorts) are the adrenals. We DO have an evolutionary precedent toward being prepared for an emergency need to raise blood sugar. If we're being chased by a sabre-toothed tiger our brain and muscles need a lot of glucose to fuel our escape and survive the emergency. Our adrenals fire to produce adrenaline (the "fight or flight" hormone), which in turn mobilizes glycogen very rapidly from its stores in the liver to help us survive. This was a mechanism designed to be implemented only in emergencies.....yet our modern day diet invokes this response in many several times a day. Our adrenals were never designed to manage our blood sugar day to day, as is so commonly the case nowadays. The result is both cravings (following the blood sugar lows after unsulin surges), chronic anxiety issues in many, hypoglycemic tendencies early on and eventual insulin resistance and diabetic changes. One in three individuals in our culture either are knowingly diabetic or are diabetic and don't know it. Many more suffer from varying levels of pre-diabetic tendencies.
Monosaccharides such as glucose have a high glycemic index and therefore stimulate insulin most efficiently. Fructose, on the other hand, has a very low glycemic index which, on the surface of things sounds like a good thing. This means that you can eat a piece of fruit without invoking much of an insulin response. Nice. This becomes problematic, though, when concentrated fruit juice is consumed---a most unnatural thing (our ancestors never would have thought to separate the pulp from the juice in this way). The result is an unnatural concentration of sugar in the bloodstream that is slow to leave and is therefore capable of doing much oxidative damage. AGE's (Advanced Glycosilation End-products) are produced by sugar molecules reacting and combining with proteins in the bloodstream. These are thought to be primary generators of aging and degeneration throughout the body and can ruin your arteries and heart in fairly short order, not to mention other vital organs. We were never meant to consume fructose in so concentrated a fashion. Fructose is, in fact, 20-30 times more glycating than glucose. --Think about that next time you consume anything containing "high fructose corn syrup" (which is actually a combination of fructose and dextrose and is also thus partly insulin stimulating)...which is, by the way, the #1 source of calories for most Americans and is creating diabetics in droves.
A single serving of straight grape juice contains about 40 whopping grams of sugar (mainly fructose). --That's EIGHT TIMES what is normally allowed in the bloodstream at any given time. It's bad enough when insulin is asked to react to something like this, as large amounts of insulin creates its own brand of arterial damage, as well as the other cascade of events mentioned. But being primarily fructose, it can be argued, is actually worse--By virtue of its low glycemic value it does not stimulate much insulin and, subsequently, does not get removed from the bloodstream very quickly. It is therefore allowed to react much more with serum proteins and create pathological vascular changes much more quickly.
The Hemoglobin A1C blood test basically measures the chronic level of glycation in the bloodstream over about a three month window. It is much more useful as a longer term measure of pathological changes than the more commonly used "fasting glucose" marker (which is of very limited usefulness).
I am not trying to be alarmist here, only wanting to point out a potential problem with all the juice consumption that comes with taking Miracle-Mineral-Supplement 2-3 times daily for some. All this juice is not good for anyone....with the rapidity of assimilation it's almost literally like injecting sugar into your veins. In more susceptible individuals this can be very damaging---Not to mention that sugar is the primary fuel for most pathogens and cancer cells. It would be much better for all of us to be taking Miracle-Mineral-Supplement with water and lemon/lime juice, and/or a couple of drops of Stevia.