The Z-pack is strong stuff, so it most likely is working full force on day 2. I know from years of chronic sinusitis, you can have an infection brewing up there without knowing it. That is why I do nasal irrigations daily. So it was a bit suprising to me that the pulling triggered some PND and yellow drainage, after being relatively symptom free fro quite awhile. In my case I was able to take care of it with a little grapefruit seed extract and glutathione added to my irrigation.
So look on the brightside, maybe the oil pulling got the last bits of an infection to drain out, and the Z-pack and pulling might actually take care of it, and then your wife won't feel the need to get Antibiotics for a long time.