I am 3 months post-removal and experienced MS like symptoms as well. I thought I was past all that, but last night I had a "flare-up". I woke up several times during the night with either the right or left hand & arm in pins & needles or "asleep". And I wasn't laying on my arm. This happened several times shortly after removal, but I hadn't experienced it in well over a month. I am due to start my 4th cycle soon (post-removal), so I have a feeling it's connected to that. It is unsettling though to say the least. It sounds like your wife has really had a terrible time and I hope she feels better soon. Hopefully, knowing that many other women have had a similar experience with Mirena will bring you and your wife some comfort.