I started only once a day, in the morning but I don't have KP. My husband DOES have KP and he went full steam ahead with twice a day, morning and night. He did not have any bad side affects and its been 2 months I think? Maybe. anyway his KP is GREATLY improved, bumps were almost gone by the end of the first month and now you cant feel them at all however you can still see where they were, kinda like scars.