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Re: Anti-thelminitic ????
wombat Views: 1,240
Published: 12 years ago
This is a reply to # 1,030,105

Re: Anti-thelminitic ????

insect repellant?

Based on botanical lore of insect repellent properties, essential oil extracts from Callicarpa americana and
Callicarpa japonica were investigated. Bioassay-guided fractionation of C. americana extracts using the yellow
fever mosquito, Aedes aegypti, led to the isolation of α-humulene, humulene epoxide II, and intermedeol, and a
newly isolated terpenoid (callicarpenal). Similar work involving C. japonica resulted in the isolation of an
additional compound, spathulenol, as well as the four compounds isolated from C. americana. Heretofore,
13,14,15,16-tetranor-3-cleroden-12-al, callicarpenal, has never been identified from natural sources. In bite-
deterrent studies spathulenol, intermedeol, and callicarpenal showed significant bite-deterring activity against
Aedes aegypti and Anopheles stephensi. In addition, callicarpenal and intermedeol were evaluated in laboratory
bioassays for repellent activity against host-seeking nymphs of the blacklegged tick, Ixodes scapularis, and lone
star tick, Amblyomma americanum and results will be presented.

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