Nitric oxide can contribute to reperfusion injury when excessive amount produced during reperfusion (following a period of ischemia) reacts with superoxide to produce the damaging free radicalperoxynitrite. In contrast, inhaled nitric oxide has been shown to help survival and recovery from paraquat poisoning, which produces lung tissue damaging superoxide and hinders NOS metabolism.
In plants, nitric oxide can be produced by any of four routes: (i) nitric oxide synthase (as in animals), (ii) by plasma membrane-bound nitrate reductase, (iii) by mitochondrial electron transport chain, or (iv) by non-enzymatic reactions. It is a signaling molecule, acts mainly against oxidative stress and also plays a role in plant pathogen interactions. Treating cut flowers and other plants with nitric oxide has been shown to lengthen the time before wilting.
A biologically important reaction of nitric oxide is S-nitrosylation, the conversion of thiol groups, including cysteine residues in proteins, to form S-nitrosothiols (RSNOs). S-Nitrosylation is a mechanism for dynamic, post-translational regulation of most or all major classes of protein.
Everyone requires nitric oxide to carry out key physiological processes within the body. From a bodybuilder's perspective, nitric oxide supplementation may prove useful in increasing growth due to increases in blood flow to certain areas of the body. Signs of deficiency, on the other hand, include physical weakness and extreme fatigue. Most "nitric oxide" supplements contain the amino acid Arginine-alpha-keto-glutarate.>>
Perhaps in the presence of H2O2 or O3, the nascent oxygen reacts with NO in the body and converts it into NO2. We need NO for lowered BP and normal heart beat. So inhaling of H2O2 maybe harmful. More research needs to be done.... alternatively, we must supplement with plenty of amino acids to counteract the side effects...