THREE-STEP PLAN TO REVERSE NUCLEAR CATARACT WITH EYEDROPS
(1) EV06 eyedrops to break lens disulfide bonds and soften the lens.
This would allow (2) and (3) below to penetrate the lens.
Contain lipoic acid choline ester.
Bought by Novartis Pharma (which also has a huge surgical lens business) as an eyedrop to cure presbyopia for $465 million. Has already passed Phase II clinical trials in the US, but Novartis says it hasn't. Novartis has no plans to release this eyedrop which is therefore unavailable.
(2) AGE-crystallin crosslink breaker. Would contain phenacyl thiazolium bromide (PTB, synthetic) or chebula (Ayurveda, natural), or any other crosslink breaker. PTB was shown, at the University of Arkansas in 2008, to break crosslinks of AGEs with alpha-crystallin, and thereby reverse loss of chaperone function of alpha-crystallin. This discovery is the key to curing cataract blindness in 90 million people worldwide and alone is worth a Nobel Prize. The eye profession has no plans to use this discovery, therefore no intention to cure world blindness, and it is therefore unavailable.
(3) Alpha-crystallin stabilizers (sterols)
This means lanosterol and other sterols. They have the ability to refold and stabilize alpha-crystallin liberated by (2) from its shackles to AGEs. Once stabilized, alpha-crystallin will then interfere with the electrostatic attraction between beta- and gamma- crystallin protein molecules by masking the electrical charges on their surfaces, thereby separating the molecules, and breaking up large molecular aggregates into smaller ones. This will restore optical transparency to the lens, curing the cataract.
Lanosterol eyedrops are available, but cannot work on alpha-crystallin until the lens is firstly softened, and the alpha-crystallin is secondly released from its bonds to AGEs (Steps (1) and (2)) above.
My cataracts are yellow nuclear cataracts. I excerpted the following from an article which appeared in 2011:
"The ageing lens and cataract: A model of normal and pathological ageing"
"(b) Nuclear cataract
Strictly defined, a nuclear cataract is a lens opacity confined to the true nucleus of the lens whose shape is determined by the concentric arrangement of the fibres that compose it. Since the light-scattering properties of the lens nucleus increase progressively after the fourth decade, the point at which an increase in light-scatter may be designated a nuclear cataract becomes a matter of clinical judgement. While in some respects the molecular basis of nuclear cataract may be seen as an extension of those age-related events responsible for increased stiffness, light-scattering and coloration of the lens nucleus, it is the oxidative events discussed above, facilitated by the lack of nuclear GSH, that are the hallmark of nuclear cataract . These are responsible for the formation of mixed disulphides and PSSPs, high molecular weight aggregates and increasing protein insolubility, which lead to lens opacity and the augmented accumulation of chromophores. These changes occur within the fibres of the lens nucleus with limited structural effect, which explains the gross morphology of the cataract".
In the same article, we find:
"With increasing levels of oxidative stress, proteins become thiolated by GSSG, cysteine and to a lesser extent γ-glutamyl cysteine, to form the mixed disulphides, PSSG, PSSC and PSSγGC . These mixed disulphides may be further oxidized to form protein–protein disulphides (PSSPs), which are found increasingly in the high-molecular-weight, water-insoluble (WIS) fraction of the lens proteins, containing large, light-scattering, protein aggregates ".
First we remark that "disulfide bonds" can be broken by sulfites (the preservatives found in wine), and by a "sugar alcohol" known as "erythritol" (which is used as an artificial sweetener). There are even eye drops for dry eye which contain erythritol. Such eyedrops also contain electrolytes like potassium citrate that would interfere with the electrical attraction between proteins. It is this electrical attraction that causes the proteins to aggregate and form a cataract (so electrolytes are a very good idea), but sometimes also calcium chloride (I don't like the idea of dosing the eye with calcium salts, especially since calcium salt microspheres trigger macular degeneration). This more or less disqualifies these eye drops. But the next paragraph gets more interesting:
"Mixed disulphides and protein disulphides of this kind can be partially restored to their native state by two key redox repair systems. The GSH-dependent enzyme system, TTase, also known as glutaredoxin, exists in cytosolic and mitochondrial forms and catalyses the dethiolation of PSSG. The GSSG formed is recycled to GSH. Lens epithelial glyceraldehyde-3-phosphate dehydrogenase (G3PD) activity can be restored by TTase after H2O2 challenge, as may other SH-sensitive glycolytic enzymes such as hexokinase and pyruvate kinase .
The NAPDH-dependent enzyme TRx, present in both cytosolic and mitochondrial forms, reduces intra- and inter-molecular protein disulphides (PSSP). TRx is restored to its reduced state by TRx reductase (TR), with NADPH acting as a hydrogen donor. TRx works cooperatively with TTase to restore protein structure, conformation and function. Like TTase, TRx activity is also upregulated in response to oxidative stress. Both TTase and TRx systems can reactivate G3PD oxidized during the exposure of human epithelial cells to H2O2. Their activity, together with that of GR, falls with age ."
Therefore, apart from sulfites and erythritol, we see that the two enzymes TTase and TRx can at least "partially restore the protein disulfides to their native state". As noted in other posts, those two enzymes are found in brewer's yeast, which explains why brewer's yeast supplements are used to treat cataract.
When it boils down to it, this 40-page article is a thorough, in-depth evaluation of nearly all aspects of our problem - although the fact that cataract aggregations are largely the result of electrostatic interactions between lens proteins (Murugappan, 2010) is not mentioned. What is frustrating, as usual, is that the authors, despite having a complete understanding of cataract and the tools to reverse it at their disposal, MAKE NO ATTEMPT TO DO SO.
What is even more amazing: This article is published in the "Royal Society - Philosophical Transactions". But our lives depend on this information - there is nothing 'philosophical' about it.
I would like to suggest a second step after using AGE-breaker eyedrops.
The previous Japanese experiments with aminoguanidine or organic germanium (germanium sesquioxide) were only able to achieve a temporary restoration of lens clarity. This is not surprising because the AGEs were not removed from the lens - they merely recombined with the lens proteins (crystallins) when the experiment was stopped, and the lens became opaque again.
The growth of a cataract is largely due to the failure of the pump at the back of the lens, the so-called Na+/K+-ATPase pump, whereby the lens acquires nourishment from the aqueous humor and discharges waste products back into it. Were we to free up the crystallins from the shackles of the AGEs with eyedrops, preferably containing nanoparticles of AGE-breakers like water chestnut extract, we would still have to remove the AGEs from the lens. I believe this could be done by reactivating the lens pump - in other words, by re-establishing circulation within the lens - by consuming Chinese or Japanese traditional herbal medicines such as "Hachimijiogan". I found a reference on the Net stating that "Hachimijiogan" ("Ba Wei Di Huang Wan" in TCM) does reactivate the lens pump. Alone, oral consumption of these herbals might not have much effect in cataract, but combined with the use of AGE-breaker eyedrops, there may well be significant cataract reversal and permanent restoration of lens clarity.
I know it's very naughty, but I can't help wondering how many practising cataract surgeons, who continue to hypocritically extal the virtues of cataract surgery, have had the surgery themselves? How many have lost their natural lens, and now got IOLs?
And what about top ophthalmologists at international conferences who pompously lecture spellbound audiences on their surgical techniques? How many of them, and their audience? Not to mention all those researchers at all those universities studying the mechanism of cataract for the last 50 years, whose discoveries never saved a single cataract sufferer from the knife - not even one - yet smiling at us like Cheshire cats in those charming group photos, all decked out in their white lab coats, on their websites. How many of them have lost their natural lens to the knife?
It rather tempts me to say, before I succumb...I think you, Doctor, should have the surgery first.
After you, Doctor...
I know I have said this many times before, but now we are in the New Year 2018, I feel it bears repeating once again. The eye profession continues to profess ignorance as to its responsibility to restore the natural eye lens without resorting to its surgical destruction. In my opinion, every ophthalmologist should be seeking a way to do this, but I personally do not know any ophthalmologist who is aware of this responsibility to humanity, or if he is so aware, who admits it.
In the past, there have been maverick ophthalmologists who were aware of this responsibility, and did something about it. Two of them successfully used color ray therapy on thousands of patients, one for four decades, but since the treatment was highly individualized and these doctors passed away in the last century, we cannot avail ourselves of that treatment. Another used nutrition, and successfully overcame cataract using this method for four decades until he passed away in 2010. The eye profession arrogantly denies any knowledge of these successes, nor has it ever shown the slightest interest in how they were achieved.
It is highly ironical that today, in 2018, we have less means available to successfully treat cataract non-surgically than 70 years ago, when these great doctors were alive.
This is very interesting. I have optic nerve atrophy in my both eyes from the beginning since I was two years old from a near fatal fever. I am now legally blind. I saw your posting last month which broke the insight (sound) barrier. For 18 months I have been bothered with hovering of graying of my black colors and losing my vision permanantly with the help of diabetes. After unlimited miles of surfing the net for this landing on the beach of this particular posting. I decided there was nothing to lose since God does not charge anything for healing. So I tried to use the castor oil on my eye lids. Then I learned she used foxbrim certified organic 100% pure Castor Oil so I switched to it. Since she said her eye pain left the next morning after the first application. My experience is similar. Instead of pain I had graying of black colors. For me the next morning after my first rub of oil over my lids the color gray quickly changed to more black. It has stayed black as long as I keep applying the oil over my eyelids every night. It changes a little more or less I guess affected by detoxing activity. I am heading into my second month in January with application of castor oil.
I am not expecting two month waiting period before it may start improving since I've had this condition for 66 years. I know full well there is no age limit for healings because we still have our Great Physician here to help us. This will be a 'hold my breath' experience.
by Tony Isaacs (The Best Years in Life) A number of conditions can lead to poor vision and eye health, including near-sightedness, far-sightedness, macular degeneration, presbyopia, glaucoma, astigmatism and cataracts. As we age, we become increasingly susceptible to many of those problems. However, contrary to popular mainstream dogma, such conditions can be prevented and often even successfully reversed. To read this entire comprehensive and extensively researched article:
author of Cancer's Natural Enemy
by Tony Isaacs
(The Best Years in Life) A number of conditions can lead to poor vision and eye health, including near-sightedness, far-sightedness, macular degeneration, presbyopia, glaucoma, astigmatism and cataracts. As we age, we become increasingly susceptible to many of those problems. However, contrary to popular mainstream dogma, such conditions can be prevented and often even successfully reversed.
To read this entire comprehensive and extensively researched article:
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