My nurtitionist has her people drink a whole bottle at 9 PM before the flush. So, I guess if you were going to split it out, 1/4 of the bottle at each time. But my experience with the cleanse was that at 9 PM was a better time to take the Epsom Salts
/mag. citrate because it's right before you have the flush and it will open the bile ducts then. I didn't even bother to do anything on the fourth time because I was already moving everything so quickly.