I am on it now for Crohn's and have been for at least 8-9 months to extend time periods between remicade treatments. I have had no real problem with it. Maybe a little fatigued at times. Also, some extra bleeding seems to occur with me...bruising, bleeding from the slightest cut or impact, but nothing serious. It is supposed to be immunosuppressive, but I haven't had even the slightest cold since I started on it. Your doc will test your blood count and liver regularly.