I have used one month worth of colonix program, and I have not experienced any problems whatsoever. In fact, I thank Colonix for getting my intestines back into shape. It cleaned me out, and gave me the opportunity to change my ways and cure myself of constipation, and acne. When i make the money I will definately buy myself another month. (3 months recommended.) Its just good to have. I go every day now, even without the Colonix; before I went about once every three days. Just make sure to drink lots of (Warm) water, and eat more fruits and vegetables. It has worked wonders on me, and hope it can do the same for you! peace.